i would actually say getting your throttle response snappy at low-mid rpm is the hardest part of tuning a carburettor, which relies on airspeed (which you change by modifying the throats) and amount of fuel being supplied at the time, which both the jets and the accelerator pump are responsible for in this instance. even some factory installs of carbs have a tendancy to "bog down" if you floor the acclerator pedal, as there is too much fuel, too much air, or both. this is from me who doesn't run a choke anyway
there are different types of carbs, mainly downdrafts which suck air from the top, add atomised fuel to it and the mixture comes out the bottom. things like holleys and dominators are downdrafts, as well as alot of webers like DGVs and IDAs. sidedrafts and SUs (skinner union) suck air in from the side and it comes out the other side, these have names like weber dcoe and dellorto. there are also updraft carburettors but these are less common and i don't know anything about them
it's generally accepted that sidedraft webers and dellortos are about as good as you can get. they have superior atomisation to almost every other carb out there, so you get a better burn and make more power for the amount of fuel you're using. on a four cylinder (or straight six) you're going to be sucking from the side of the head anyway, so a sidedraft has a less restrictive intake tract than a downdraft, less restriction is good. v8s i would expect a downdraft would be a better option, as there are millions of manifolds available for them, and their inlet ports are in the middle of the "valley"
most carbs have throttle butterflies, which open and close gradually to allow an amount of air down the venturiis (skinny part of the throats that causes pressure drop). a decent replacement for sidedrafts is SU carbs, which have a sliding venturi type design, and work partially off vacuum. most old carb experts can tune SUs perfectly by ear, however they have a tendancy to go out of tune fairly quickly
compared to efi, carbs are a compromise. they will be as efficient as efi at WOT (wide open throttle, or full airflow capacity) providing you get your fuelling right. but anything below that (circuit driving, town driving) they will not be as good. that being said, you can stay up to all hours of the night tuning carbs yourself, it costs you nothing, and it's fairly easy once you spend alot of time learning how. as opposed to having a programmable computer that you need to pay someone else to dyno tune during business hours only
alot of amateur racers run carbs for this reason. it's acutally quite amusing to turn up to a track day to see an old escort or something, with a modern sr20 or similar, with a dirty pair of carbs slung off the side

even open wheelers with big-dollar rare genuine cosworth engines run carbs, so it's not like you're restricting yourself by using them