My Fat 60 YLOD'd the first night GT5 came out, and wasn't even nearly hot when it did so, I suspect it was the PSU (power supply unit) that packed up. I didn't bother fixing it because it was already 4 years old, once you fix the PSU then the BGU (ball grid array) desolders itself, then you fix that and the blu ray laser burns out, you fix that then who knows what else will die?
So I took it on the chin, bought a 160gb slim and I haven't even gone back to Black Ops since, GT5 is all I've played on it so far. But yeah, every major release has killed a PS3, my reasoning for that is this.
If 5% of PS3's ever made will die (uneducated guess), more of those 5% will be playing a big release like GT5, Heavy Rain, Uncharted, Call of Duty or Killzone than they will be playing something like Arkham Asylum or Just Cause 2, so naturally when a lot of people buy one game, more failures occur while playing that game, so everyone thinks that game is killing PS3's.
I put mine down to age, frankly I'm surprised it lasted that long, being a launch model and the amount I play would stress any system, hence why I got the 3 year warranty on my new slim!