Personally I'm not aware. Whether it happened earlier, I have no idea but in recent memory (in my case that would be maybe 20-30 years) I can't recall anything like that. As far as I'm aware, all motorcycle races are held on the Bugatti Circuit, that also happens to be a permanent one, unlike the full Circuit de la Sarthe. MotoGP races there, WSBK did race there and of course, there the 24h Moto, one of the round of the FIM Endurance World Championship.
Given the nature of the full circuit and the fact that a big portion of it is closed public roads, I can't see motorcycles racing there.