They carry massive amounts of fuel. Tractor-Trailers don't spend that much time in towns anyway, as they're usually found on the interstate in cruising gear. The emphasis lately, though, in the truck engine industry, has been power and emissions. Cat's gone to sequential twin turbos (think Supra or 959) on their 6-cyl highway engines. I was at their Mapleton, IL factory last night, so I know.
They accellerate rather well, (Cat's coming out with a 600hp engine with GOBS of torque, and they make sizes up to 18L. Not 1.8L, 18L.) as long as the driver knows his gears. Highway on-ramps are made for trucks to accellerate well, too, and you often find guys on the plains doing 70, 80 mph. Hell, even in Missouri's Ozarks.