I've heard that you can't die of an aspirin overdose. You'll vomit the contents before it can all get in the bloodstream. However, it is potentially lethal to mix large amounts of aspirin with large amounts of alcohol.
I used to know a fellow who was a typical nice guy, but he was immensely overweight, had no life, no money, lived at home. He quit his job at my store about 8 years ago because they wouldn't give him a raise. About 2 weeks later, he tried to kill himself by overdosing on aspirin. He said, "I felt terrible, eventually felt worse, and was pissed off when I woke up sicker than before, but alive. Shit!"
Well, last I heard, he went back to school and wanted to make something of his life.