First, I would like to say you all rock. Family Guy is grand and you all rock for liking it.
There's Something About Paulie:
Bachelorette: "If I was ice cream, how would you eat me?"
Peter: "I would eat you really fast before I got flacid."
Doctor: "Thats not a growth Mr. Griffin, that's your penis."
Peter: "Oh... Hrm... And the..."
Doctor: "Testicles."
Peter: "Oh... Huh."
Lois: "Did you take care of the mob hit?!"
Stewie: "Oh my! There are so many people to thank! God, of course. Oh my, this is so unexpected *Stewie grabs sheet out of his clothes*. Oh yes, SATAN."
I could fill this whole thread with favorite lines, but those are some of my favorites and came to mind.