Mainly just tire and downforce strategy. Lower downforce is better for tracks with lots of long straights, and high downforce is better for tracks with more turns.
If you have problems with rear slipping, you can add 3 ballast and -1 on the front. Works a charm. Downforce in this game doesn't work as intended and you won't see any difference in speeds from my experience, but some better handling. Even in stock this car sticks like glue