I always set my t300 wheel to low weight (25 in game, the first slider after gain, but the gain must stay at 100 at all times in pc2 regardless your setup). I can have effects and other things from low to medium strength too, but the wheel weight always from medium to light depending on the car.
It is true that you burn calories and might sweat a lot (on summer) while sim racing, but just like with any other workout at an age, you must be careful.