He means Region 2 and Region 3. He also means, "any way" not "anyway".
I've had no experience with using different discs from different regions, but I would expect the data to not be compatible. The reason that they have regional games and movies is to avoid illegal copying and distributing.
You might find that the other disc might not even work on the system that you have. Most likely the data itself is locked to the R2 disc and is incompatible with the R3 disc.