That's what I have been running. Ran on R1 tires last night for a few races, and just before I planned on switching them back to S3's I ran into a couple Clio's. Needless to say I kept the R1 tires on, and still finished second by ~3 seconds.
I've been having pretty good results with the NSX, hard to pass the Clio's especially when they are running Race tires, but the NSX is so neutral and fun to drive on S2's.