The story features two possible endings, each of which features different missions depending on choices made by the player at this point in the game. The player can choose to exact Revenge on Dimitri or make a Deal with him.
If the player chooses to exact Revenge, Niko ambushes Dimitri on his tanker while he is supervising a shipment. A gunfight ensues within the hull of the tanker and Niko kills Dimitri in cold blood. In the aftermath Roman and Mallorie's wedding takes place and Jimmy Pegorino, furious after the betrayal, kills Kate McReary. Niko, Roman and Little Jacob visit the abandoned casino in Alderney to take down Pegorino, but he escapes to Happiness Island. Niko chases after Pegorino and a final confrontation takes place at the base of the Statue of Happiness, where Niko executes Pegorino.
If the player chooses to strike a Deal, Niko with the assistance of Phil Bell meet at the docks to make the exchange, however the deal is ambushed and Niko and Phil eventually retrieve the drugs money. Phil later calls Niko, saying that he must cut all ties with him due to a recent furor in the Pegorino family. Kate, who was against making the deal, is furious with Niko and vows never to see or speak to him again. Roman and Mallorie's wedding takes place and Dimitri's henchmen arrive to assassinate Niko but end up killing Roman instead. A devastated and vengeful Niko teams up with Little Jacob to take out Dimitri and Pegorino, who escape to Happiness Island. Dimitri executes Pegorino and a final battle ensues between Niko and Dimitri, who meets his fate in an alternate, darker and more sinister ending to the storyline.