Great thread!
I gotta give props to just about all the suggestions, especially "Kitt", the original "Batmobile", the "Ecto-1", the Gran Turino from "Starsky & Hutch, the futuristic "I, Robot" Audi, and the Ferrari from "Ferris Beuller's Day Off".
Here's a couple more I didn't see mentioned...
1. What about the car from the classic "Spy Hunter" video game?
(Your pit-stops could be in the back of that truck...)
2. Back to "Ferris Beuller", how about the Plymouth Ed Rooney drove, or even that Pontiac Fiero his sister had?
('I asked for a car and I got a computer. How's that for being born under a bad sign...')