Renault has the least chance of messing it up, they have the most money, have plenty of experience running V6 turbos as a company and experience at the front of the pack.
I'd be more afraid of Ferrari getting it wrong with their limited, recent, experience running forced induction and V6s.
Honda's not in the game till 2015 at the earliest, no telling how well they'll do, but judging through history and what they're good at, it should be great.
The only thing I'd be afraid of with the all new RB10 is that it may be unreliable. It took them a while to get the kinks out of the RB6 and beyond series of cars, so it could be a reset in that department.
Still, with everyone in their place, I highly doubt Vettel will go anywhere until 2017 when Alonso's out, but things could change drastically at any time up to that point.