I've been testing various cars with various tires for about one year now. I started this in GT5, trying to find best real-life equivalent tires for each car, based on lap times. Mostly on Tsukuba, but also at Nordschleife, Suzuka and Laguna Seca. I've literally spent nights comparing my in-game laps with real ones, so I would like to make couple of points:
1. Comfort Tires are more grippy in GT6, than they were in GT5 on most cars. Also the weight of the car has bigger impact on car's handling. Lighter cars are generally much faster on same tires in GT6, than in GT5 - Lotus Elise 111R on Comfort Medium is a great example, also '02 NSX Type R - on Nordschleife on CM I was able to achieve time of 8.03 in GT5 (7.56 to the line after last corner - like almost all Nurburgring lap times are measured). In GT6 I get 7.55 at second lap I've run.
2. Tsukuba seems to be best for comparing lap times, because there is a lot of Best Motoring videos on the internet, also many lap times can be seen for example on fastest laps site. But, there is a but

Tsukuba lap times vary up to 2-3 seconds for the same car because of track conditions, mostly the temperature. For example Honda NSX Type S Zero record is 1.05 seconds, achieved in dry conditions in winter with temperature of 0 to 1 degree Celsius. The same car in hot, summer day (24-26 degree Celsius) can achieve 1.07 to 1.08 seconds. I don't know, if the temperature influence on handling is modelled in GT6, but track information before the race shows about 25 degree Celsius in game. Thinking logically, it shouldn't be possible to achieve record lap times, that were set in winter conditions in reality, in same car wearing most close-to-stock tires in the game. And this attitude appears to be working in most cases. For example:
Car: Honda NSX Type S Zero '97, CM tires, only ABS set at 1, rest turned off
- Tsukuba: Real life record time - 1.05, my record in game - 1.05.6 (0.6 seconds slower, it was very hard to achieve such a fast lap)
- Suzuka: Real life record time - 2.34, my record in game - 2.31 (3 seconds faster)
- Nordschleife: Real life record time - 8.10, my record in game - 8.11 (8.07 to the line after last corner, so 4 seconds faster)
I've used this car as an example, because it's very skittish, and hard to drive, for me at least. But even with car this hard to control I've managed to set faster lap times on 2 of 3 tracks.
My conslusion is - that some lap times on Tsukuba cannot be achieved, while using the most true-to-life in-game tires, because of the fact, that in reality they were set on much better track conditions, than conditions available in game.
3. Many cars can achieve better/slower lap times in game than in reality, not only because of the tires. For example - Toyota Supra RZ '97. Almost all 1990's JDM sport cars like NSX, GTR, Lancer, Impreza etc. feels, and can achieve very realistic lap times on CM tires. But with the Supra, there is a problem. It's a lot slower on CM than it should be. The problem is messed up weight distrribution, which in game is Front/Rear: 60:40. In real life it should have 53/47 for turbo (RZ) model. When you correct this, by installing weight reduction and then adding balast to the rear, suddenly all seems to work just fine. With correct weight distribution I'm second faster on Tsukuba, and I can easily set lap time of 1.44,5 on Laguna Seca (1 sec faster than real-life record). I'm writing this because weight distribution and weight itself has very big impact on car's handling in GT6.
4. From what I've tested on both GT5 and GT6, and I have really driven a lot of stock cars, if You want to have tires that match the reality (of course considering lap times), majority of cars should wear Comfort Medium tires. Comfort Soft match almost perfectly 458 Italia, Corvette Zr-1, Lexus LFA, Enzo and this type of thing. The only stock car,that I've found so far that sets realistic lap times in game on Sports Hard tires is the Viper ACR, maybe also the LFA Nurburgring Edition with its 7.14 Nurburgring lap record, but I haven's tested it yet. Even 7.18 record of 2012 Nissan GT-R can be set on Comfort Soft Tires (In Gt at least). There is a lot in-car record laps at Nurburgring available to watch. If you want, try to set best lap time that You can, than compare it to real life lap. Watch your best lap in replay and real life footage simultaneously, and check for yourself. I assure You, that on Sport Hard You will be a lot, lot faster than driver that drives in real car. And yes, I agree that fear takes part in real "Green Hell" lap, but the much better grip of SH tires in game is most visible in slow corners, and during braking. I just don't think real racing driver would fear THAT MUCH

Great example of this is 1990 Acura NSX 8.16 lap set by Gan San. I've set about 3 seconds slower lap in game on CM tires. Then I played real footage on my computer, and my lap in replay mode in cockpit camera. And You know what? It was fantastic to see exact moments of turning, even the braking points and downshifts were done in almost the same moments

That really felt, like I'm as fast, and as good driver as Motoharu Kurosawa

My lap time was slower, not because of worse handling by CM tires, but by the fact, that in game 1990 Acura NSX was slower in the straight lines (yes, it's not always that cars in GT are faster on long straights).
5. Polyphony Digital gave us information about most close to life tires 3 times during the GT5 period:
- During the Toyota GT-86 competition in Japan CH tires were used as most close to life counterparts
- During the SLS AMG event on Top Gear Test Track GT5 players used CS tires. David Coulthard was in fact faster in real life, but as you can see from the footage, he was cutting like hell. Players weren't allowed to cut corners in way that he did
- Audi R8 V10 at Laguna Seca - PD said that CM (yes, I know it's hard to believe, as it was for me) are closest to real stock tires. Link:
https://www.gtplanet.net/forum/thre...-gt5-virtual-v-reality-at-laguna-seca.227775/
I'm sorry for such a long and boring post

, and also for my not very good English. I've felt that after so many days I've spent trying different tires on different cars I have to share my conclusions and results. Maybe for some of You, who enjoy driving stock cars on realistic tires in GT6, this post will be helpful. In a couple of months I will post a list of cars with closest to reality tires based on lap times, if someone will be interested. Of course it would be great, if Polyphony Digital gave us this kind of information, but they didn't, and I doubt they will. And it's not that it seems that they don't know, considering how close the laptimes are to reality, when using right tires.