@Kent
You need to retexture the game to really improve the graphics. I use
"GraFix Texture Overhaul 2.0" http://www.nexusmods.com/fallout4/mods/1764/?tab=1&navtag=http://www.nexusmods.com/fallout4/ajax/moddescription/?id=1764&preview=&pUp=1 This will sharpen and increase the contrast of the vanilla textures.
I also use Reshade presets. I already tried most of them now even the not so famous presets and I settled to this for now
"Alone" La Zona http://www.nexusmods.com/fallout4/mods/310/?tab=1&navtag=http://www.nexusmods.com/fallout4/ajax/moddescription/?id=310&preview=&pUp=1
If you want the vanilla look but clearer and sharper, no milky white tint that artificially brightens the view, I suggest using this.
"Clear Fallout 4 with Fog Tweak" https://sfx.thelazy.net/games/preset/4715/
Best tweak tools.
1. Fallout 4 Tweaker (Nexus Site)
2. Shadowboost (Nexus Site)
3. Nvidia Control Panel for Nvidia GPU users
4. RadeonPro for AMD GPU users (can be used with Nvidia)
5. Texture Load Workaround (Nexus Site)
6. ENBoost (I forgot!

)
I have tons of retexures and mods I can't list them all
So I will just list my other mods that I use (excluding the first two) to enhance the games graphics. These are found in Nexusmod Site for those who doesn't know.
1. Darker Nights
2. FAR- Faraway Area Reform (LOD)
3. Radiant Clouds and Fogs
4. WET- Water Enhancement Textures
5. Fallout IV Gore Texture Overhaul
6. Fallout Texture Overhaul Pipboy UHD 4K Dark
7. Fallout Texture Overhaul Stars- FTO Stars 4K
8. New Road Enhanced
9. Street Signs Retexture
10. Dynamic Weapon Shadows
11. Enhanced Grass
12. exShinra's Better Road Textures
13. F4- Remove Interior Fog
14. Mega Explosions
15. Heavy Rain
16. Pipboy Shadows
17. Realistic Lights
18. Vivid Fallout Rocks 2K
19. 4K HD Enhanced Blood Mod
20. D.E.C.A.Y. -Better Ghouls
21. Brighter Settlements
22. Fallout Texture Overhaul Moons- FTO Moons Masser and Secunda 4K
23. Better Handmade Weapon Textures
24. Better Quarry sights
25. Better Computer Terminals
26. Improved Map with Visible Roads -Darker Version
27. 4K and 2K Safe Retexture
28. Pinup Better Pictures
29. Wasteland Salon -Hair Texture Improvement Mod
30. 4K HD Textures -Power Armors
31. E3FX SSAO and HBAO Add-ons
32. (some body retexture)
Here are some Reshades that I've tried.
Also found in Nexusmod Site.
1. Cinematic Excellence
2. Decay (
like this)
3. Photorealistic Wasteland
4. Truewasteland
5. Uber Fidelity Suite (
like this)
6. Vintage Film Looks
7. Wasteland Grit
8. Uraniumfever (SweetFX)
9. Quentin's
10. Vogue
11. Shadow of Boston
12. The Love of Eli (
like this)
13. Ultimate Engine
14. Stalker Lighting (Photorealistic Wasteland)
These are a must to improve the sound.
Also found in Nexusmod Site.
1. Towbie's Realistic Weapon Sounds -Realistic Bullet Cracks
2. Louder Rainy Sound
3. P.A.M.S. Power Armor Movement Sounds
4. Silent Generators and Turrets
I haven't included all the mods yet as I have another batch of mods to be installed. As of now these are the better graphics and audio enhancement mods out there. I will share the other mods that I find useful in another post.