My question is what is next after the second or perhaps third part of them vs. Thanos. Thanos will clearly collect all the gems this movie by the end, it's the development and building of it that I'm in for. The second (if there is no third) will be how do they beat a IG Thanos, if they take from the source material they'll need someone on level with Adam Warlock, and none of the characters seen are that. Doctor Strange perhaps but he and Vision are powerful because of their gems it is seen so far, not for the same reasons they are in the comics, so it's hard to see them being able to fight Thanos after losing said gems.
It's a roller coaster and that's why I think it will be fun to watch even if you can predict how it will play out, cause of Marvel/Disney wanting to milk it and the general history of these characters.